Evolve is set on Shear, a distant planet that humanity has travelled to in the distant future and is attempting to colonize. The colonies are soon attacked by malevolent alien Monsters, who do not take too kindly to having their territory invaded. As the Monsters attempt to drive these invaders away, a team of elite Hunters—consisting of war veterans, psychopaths, professionals, and expendables—are assembled to eliminate the Monsters, setting the main conflict of Evolve.